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Description

  • GeneName: ADRBK1; GRK2; BARK1; FLJ16718; BETA-ARK1; BARK.
  • Adrenergic, beta, receptor kinase 1; Beta-adrenergic receptor kinase 1.
  • beta-adrenergic receptor kinase 1; beta-ARK-1; OTTHUMP00000235171.
  • G-protein coupled receptor kinase 2; adrenergic, beta, receptor kinase 1.
  • Clonality: Monoclonal; *Isotype: IgG; *Clone: 6k13; *Source: Host: Rabbit; Source: Human.
  • Reactivity: Human, Mouse, Rat.
  • Form: Supplied as a liquid ; *Purity: Supernatant Supernatant.
  • FREE-8GB-USBDrive for this item. Item is for research use. NOT for diagnostic/therapeutic procedure..
  • Imported from USA.
SynName: Anti -Adrenergic Receptor Kinase, beta 1 (bARK1, B1 AR, ARK1 beta, G Protein Coupled Receptor Kinase 2, GPCR K2, GRK2); Adrenergic Receptor Kinase, beta 1 (bARK1, B1 AR, ARK1 beta, G Protein Coupled Receptor Kinase 2, GPCR K2, GRK2); *Tested: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS); *AppNotes: Suitable for use in Flow Cytometry, Western Blotting, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Dilution: Flow Cytometry: 1:100 Western Blotting: 1:500 Immunohistochemistry: 1:100-250 Immunocytochemistry: 1:100-250 Immunoprecipitation: 1:80; *Specificity: Recognizes human B-ARK1Immunogen: A synthetic peptide corresponding to residues in the C-terminus of human B-ARK1; *Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. ; *Accession#: P25098; *Description: Adrenergic receptor kinase (beta-ARK1) also known as GRK2 is part of the G Serine /Threonine protein-coupled receptor kinase family (1). B-ARK1 specifically phosphorylates G protein-coupled receptors in their activated form (agonist-bound state). Phosphorylation occurs in the carboxyl terminal tail of the receptor(2). Additionally, phosphorylation of the receptor by B-ARK1 requires beta-Arrestin to induce complete homologous desentisization(3).; *NCBI Summary: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal co...
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Adrenergic Receptor Kinase, beta 1 (bARK1, B1 AR, ARK1 beta, G Protein Coupled Receptor Kinase 2,...

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